The study aimed at evaluation of expression of Survivin in different grades of oral squamous cell carcinoma in which biospied tissue of 43 confirmed cases of Oral squamous cell carcinoma was taken and immunohistochemical expression of Survivin was seen.
The word ‘Cancer’ has created a fear in society. The reason being, its decreased survival rates, especially if detected at later stages. The Oral squamous cell carcinoma (OSCC) is one amongst common head and neck cancers and shows poor prognosis despite advancement in treatment and diagnosis. One of the primary reasons for the poor prognosis in OSCC is the lack of significant and unique molecular tumor markers to assess risk and prognosis. Identification of better prognostic factors is necessary to assist clinicians in more accurate lesional staging and prediction of prognosis. Considering all this, a study was planned in identification of regulators of programmed cell death, or apoptosis, which may influence the cell death/cell viability balance in cancer. Any disturbance in normal apoptotic cycle especially the ones leading to inhibition of apoptosis, aids in growth of cancer cells.